AOD-9604/MOTS-c/Tesamorelin

Synergistic peptide stack studied for enhanced fat metabolism, mitochondrial energy, and growth-hormone signaling.

⭐⭐⭐⭐⭐Advanced Metabolic & Fat-Loss Support

Fat-Loss Support + Body Composition

AOD-9604 is commonly used to support fat metabolism and body recomposition goals alongside nutrition + training.

Recovery + Metabolic Resilience

MOTS-c is used in wellness protocols to support metabolic function, energy utilization, and recovery capacity.

Visceral Fat + Hormone Optimization Support

Tesamorelin is commonly used (under clinician supervision) to support IGF-1 signaling and body-composition goals, especially around midsection/visceral fat.

Contraindications and Precautions

Contraindications:

  • Known allergy/hypersensitivity to AOD-9604, MOTS-c, tesamorelin, or formulation excipients
  • Pregnancy or breastfeeding (insufficient safety data)
  • Active malignancy or history of cancer without explicit clearance (growth-hormone/IGF-1 related pathways may be a concern)
  • Active proliferative/severe non-proliferative diabetic retinopathy (extra caution with IGF-1 related therapies)

Use with Caution:

  • Diabetes/prediabetes or insulin resistance — monitor glucose markers as directed
  • History of edema, carpal-tunnel symptoms, or significant fluid retention tendencies
  • Thyroid disorders — ensure thyroid management is stable before optimizing body composition
  • Cardiovascular disease risk factors — discuss goal/monitoring plan with your clinician
  • Concurrent “fat-loss” agents, stimulants, or multiple peptides — avoid stacking changes too fast; introduce one variable at a time
Stack note: If you’re combining AOD-9604 + MOTS-c + tesamorelin, your clinician should outline timing, labs, and a stepwise ramp-up plan to reduce side effects and isolate what’s helping (or causing issues).

Results, Dosing, and Side Effects

Reported Results:

  • Improved body-composition outcomes when paired with a calorie plan + progressive training
  • Some users report better energy utilization and recovery consistency (especially with better sleep and protein intake)
  • Waistline/visceral-fat-focused goals are often paired with tesamorelin protocols (provider-directed)
  • Best results come from consistency: steps, sleep, nutrition compliance, resistance training

Dosing and Administration

Route: Often subcutaneous injection for peptide protocols (provider-directed).
Timing: Many protocols place GH-related therapies away from large carb/fat meals; follow your prescriber’s plan.

  • AOD-9604: Commonly used daily in wellness protocols; timing varies by clinician.
  • MOTS-c: Often used in cycles (e.g., a few times weekly for several weeks) depending on goals/tolerance.
  • Tesamorelin: Typically dosed once daily in many protocols, often evening; monitoring of IGF-1 is common.
  • Storage: Follow pharmacy instructions (refrigeration after reconstitution is common). Protect from heat/light.
Always follow your clinic/pharmacy instructions for concentration, reconstitution, injection technique, and needle disposal.

Side Effects — Common

  • Injection-site redness, swelling, itching, or tenderness
  • Headache, flushing, mild nausea, or fatigue (often improves with hydration + slower ramp)
  • Water retention or “puffy” feeling (more often reported with GH/IGF-1 pathway changes)
  • Increased appetite in some users (plan nutrition accordingly)

Side Effects — Serious (Rare)

  • Allergic reaction (hives, swelling, wheezing) — seek urgent care
  • Vision changes or severe headache — stop and contact clinician
  • Significant edema, shortness of breath, chest pain — urgent evaluation
  • High blood sugar symptoms (excess thirst/urination, confusion) — evaluate promptly

Why This Stack?

This stack is commonly positioned as a body-composition + metabolic support approach: AOD-9604 is often paired for fat-metabolism support, MOTS-c for metabolic resilience and recovery, and tesamorelin for IGF-1 pathway support and body-composition goals. The best protocols pair these with a structured nutrition plan, strength training, and measurable recovery habits (sleep, hydration, steps).

Client Note:
“The biggest change was consistency—once sleep and protein were dialed in, my weekly progress finally looked predictable.”

Practical Stack Tips

  1. Add one at a time: Start with one compound for 7–14 days before adding the next (easier to spot side effects).
  2. Track outcomes weekly: scale trend, waist, photos, training performance, steps, sleep.
  3. Do the basics: protein target, calorie plan, lifting 3–5x/week, daily steps, hydration.
  4. Lab/monitoring plan: follow clinician guidance (often includes glucose markers and IGF-1 monitoring).
  • If appetite rises, pre-plan meals/snacks so it doesn’t derail the deficit.
  • If water retention rises, don’t panic—track waist + photos + trend weight, not day-to-day scale noise.
  • If sleep worsens, address sleep first—body comp progress usually follows.

This content is informational only and not a substitute for medical advice. Follow your licensed provider’s guidance and product labeling.

Disclaimer: For Informational Purposes Only — Not Medical Advice
The content provided is strictly for educational and informational purposes. It should not be interpreted as medical advice, diagnosis, or treatment. This platform, its communications, and related materials are not a substitute for professional medical care from a licensed healthcare provider.

Always consult your physician or another qualified healthcare professional with questions regarding any medical condition, treatment, or before starting a new health program. Do not disregard or delay professional medical advice based on information obtained here.

Use of this information is at your own risk.