PT-141
PT-141: Peptide shown to enhance libido and sexual performance by directly activating arousal pathways.
⭐⭐⭐⭐⭐Clinically Proven Sexual Wellness Peptide
Potential Benefits of PT-141 (Bremelanotide)
On-Demand Option
Used “as needed” rather than daily—fits around real life and avoids continuous exposure.
Desire & Arousal Support
FDA-approved for acquired, generalized HSDD in premenopausal women; non-hormonal mechanism.
Whole-Program Friendly
Pairs with coaching on stress, sleep, meds review, and relationship context for best outcomes.
PT-141 (brand device available) is indicated for premenopausal women with acquired, generalized HSDD.
Not studied/approved for men or postmenopausal women for this indication. Use only under a licensed clinician’s supervision.
Contraindications & Precautions
Contraindications
- Uncontrolled hypertension or known cardiovascular disease
- Known hypersensitivity to bremelanotide or formulation components
- Pregnancy or breastfeeding (insufficient safety data)
Use with Caution
- Controlled hypertension—monitor; transient ↑BP/↓HR can occur for several hours
- History of nausea/migraine—start when you can rest; anti-nausea plan if needed
- Oral meds that must work quickly—PT-141 can slow gastric emptying
- Oral naltrexone users: exposure may be reduced; discuss alternatives
- Skin hyperpigmentation risk—may cause focal darkening (face, gums, breasts); usually resolves slowly or not at all after stopping
Outcomes, Dosing & Side Effects
What to Expect
- Some patients report higher desire and reduced distress around low desire
- Response varies—discontinue if no meaningful improvement after several uses (your clinician will guide)
- Best results with a full plan: stress/sleep support, meds review, and relationship context
Dosing & Administration (On-Demand)
- Dose: 1.75 mg subcutaneous injection using the on-demand device
- Timing: At least ~45 minutes before anticipated sexual activity
- Limits: ≤1 dose per 24 hours; ≤8 doses per month
- Sites: Abdomen or thigh; rotate injection sites
Side Effects — Common
- Nausea (sometimes significant), vomiting
- Flushing, headache, dizziness, fatigue
- Injection-site reactions
- Transient ↑blood pressure and ↓heart rate
- Focal hyperpigmentation with repeated use
Side Effects — Serious/Rare
- Severe hypertension, syncope—seek care
- Allergic reactions (rash, swelling, breathing difficulty)
- Persistent or concerning mood changes
Why Choose PT-141?
PT-141 offers a non-hormonal, on-demand option for premenopausal women with acquired, generalized HSDD when used within a clinician-guided plan that addresses medical, psychological, and relationship factors.
Patient Story:
“Using it only when needed felt simple. Pairing it with stress and sleep coaching helped the most.” — Camila T.
“Using it only when needed felt simple. Pairing it with stress and sleep coaching helped the most.” — Camila T.
Mechanism of Action
- Melanocortin Agonist (MC4R): Acts centrally to modulate pathways tied to sexual desire and arousal
- Non-Hormonal: Does not rely on estrogen/testosterone replacement
- Gastric Emptying: Temporarily slows gastric emptying—may reduce exposure to certain oral meds
Educational content only; not a substitute for medical advice. Use PT-141 only under supervision of a licensed healthcare professional, and stop if you experience concerning side effects.